Zip Code 49221
Adrian, Michigan — Lenawee County
📍 ZIP code 49221 is in Adrian, Lenawee County, Michigan.
ZIP code 49221 is located in Adrian, Lenawee County, Michigan. It is a zip code in the Eastern (EST/EDT) Time Zone with an estimated population of 41,041. The area code for ZIP code 49221 is 616.
Quick Answer
Zip code 49221 is in Adrian, Michigan (Lenawee County). It has a population of 41,041, median household income of $57,316, and median home value of $158,700.
Population
41,041
Income
$57,316
Home Value
$158,700
Climate
84°F / 17°F
About Zip Code 49221
Zip code 49221 is located in Adrian, Michigan, within Lenawee County. Home to approximately 41,041 residents, this area sits at an elevation of 823 ft and falls within the Eastern (EST/EDT) timezone. The local area code is 616.
The median household income is $57,316 per year, which is below the national median of $70,784. Homes in this zip code have a median value of $158,700, and the cost of living index is 62 (38% below the national average of 100).
Summers average a high of 84°F while winters drop to 17°F. The area receives about 30 in of rain and 21 in of snow annually. The zip code covers 118.4 square miles of land area and 0.7 square miles of water.
Key Statistics
41,041
$57,316
$158,700
Eastern (EST/EDT)
616
823 ft
118.4 sq mi
40.4
17,011
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Compare With Nearby Zip Codes
| Metric | 49221 | 49268 | 49235 | 49287 | 49279 | 49265 |
|---|---|---|---|---|---|---|
| City | Adrian, MI | Palmyra, MI | Clayton, MI | Tipton, MI | Sand Creek, MI | Onsted, MI |
| Population | 41,041 | 1,026 | 2,036 | 2,122 | 882 | 5,137 |
| Median Income | $57,316 | $87,250 | $63,929 | $87,411 | $69,231 | $70,020 |
| Home Value | $158,700 | $165,600 | $172,100 | $235,800 | $167,500 | $245,100 |
| Cost of Living | 62 | 72 | 65 | 91 | 65 | 96 |
| Median Age | 40.4 | 48.6 | 45.2 | 46.6 | 48.5 | 48.8 |
Cost of Living
100 = National Average. Adrian's cost of living is 38% below the national average.
vs. State Avg
Below
Affordability
Very Affordable
Income-to-Home
2.8x
Demographics
Zip code 49221 has a population of 41,041 people with a median age of 40.4. There are 17,011 housing units in this area.
Racial & Ethnic Composition
Source: U.S. Census Bureau American Community Survey estimates.
Population History
Adrian (49221) population trend from 2010 to 2024
↑ 5.8%Source: U.S. Census Bureau estimates and American Community Survey data.
Climate & Weather
84°F
17°F
30 in
21 in
Adrian experiences warm summers with average highs around 84°F. Winters are cold with lows averaging 17°F. The area receives about 21 in of snow per year.
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Housing & Economy
Median Home Value
$158,700
Median Household Income
$57,316
With 17,011 housing units across 118.4 square miles, 49221 has a housing density of 144 units per square mile. The home price-to-income ratio is 2.8x.
Location & Geography
Latitude
41.9024°
Longitude
-84.0647°
Land Area
118.4 sq mi
Water Area
0.7 sq mi
Nearby Zip Codes
Zip codes closest to 49221 (Adrian, MI) with distances:
ZIP Codes with Similar Income Nationwide
The five U.S. ZIP codes whose median household income is closest to 49221's $57,316. A way to compare Adrian to economically similar communities elsewhere in the country.
Computed from U.S. Census Bureau ACS 5-Year Estimates by the Zip Code Near Me Data Team.
ZIP Codes with Similar Demographics
The five U.S. ZIP codes whose racial and ethnic composition most closely matches 49221 (Adrian, MI). Similarity is measured by cosine distance on the five-category ACS demographic vector.
Computed from U.S. Census Bureau ACS 5-Year Estimates by the Zip Code Near Me Data Team.
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People Also Ask
What zip code is Adrian, Michigan?
Adrian, Michigan uses zip code 49221.
What county is zip code 49221 in?
Zip code 49221 is located in Lenawee County, Michigan.
What is the population of zip code 49221?
The population of zip code 49221 is 41,041 with a median age of 40.4.
Is 49221 in Adrian, Michigan?
Yes, zip code 49221 is in Adrian, Lenawee County, Michigan. The area code is 616.
Frequently Asked Questions
What city is zip code 49221 in?
Zip code 49221 is in Adrian, Michigan. It is part of Lenawee County and uses the Eastern (EST/EDT) timezone.
What is zip code 49221?
Zip code 49221 is a U.S. postal code in Adrian, Michigan (Lenawee County). It has a population of 41,041 and covers 118.4 square miles.
What is the population of zip code 49221?
The population of zip code 49221 (Adrian, MI) is 41,041 with a median age of 40.4. There are approximately 17,011 housing units in this area.
What is the median income in zip code 49221?
The median household income in zip code 49221 (Adrian, MI) is $57,316 per year. The cost of living index is 62 (100 = national average).
What is the average home price in zip code 49221?
The median home value in zip code 49221 (Adrian, MI) is $158,700. The cost of living index is 62 compared to the national average of 100.
What county is zip code 49221 in?
Zip code 49221 is located in Lenawee County, Michigan. The primary city is Adrian.
What is the area code for zip code 49221?
Zip code 49221 in Adrian, MI uses area code 616. It is located in the Eastern (EST/EDT) timezone.
Is zip code 49221 a good place to live?
Zip code 49221 (Adrian, MI) has a cost of living index of 62 (100 = national average), a median household income of $57,316, and median home values of $158,700. The median age is 40.4. Visit the full page for demographics, climate, and nearby zip code comparisons.
What is the cost of living in zip code 49221?
The cost of living index for zip code 49221 (Adrian, MI) is 62, where 100 represents the national average. This area is below the national average. Median home value: $158,700.
What schools serve zip code 49221?
Zip code 49221 in Adrian, Michigan is served by the local school district of Lenawee County. For specific school information, check your state's department of education or GreatSchools.org.
All demographic data on this page is sourced from the U.S. Census Bureau American Community Survey (ACS) 5-Year Estimates. ZIP code boundary and delivery data is sourced from the United States Postal Service (USPS). Data is updated periodically and may not reflect the most current figures. Census Bureau ZIP Code Tabulation Areas (ZCTAs) may differ slightly from USPS ZIP code boundaries.
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Data Sources
- Population, income, housing, age, and demographics
- U.S. Census Bureau, American Community Survey 5-Year Estimates, 2019-2023 vintage.
- ZIP to city and county mapping
- USPS and HUD-USPS ZIP-County Crosswalk.
- Time zones and area codes
- IANA tz database and NANPA.
- Elevation
- U.S. Geological Survey National Elevation Dataset (NED), via the USGS Elevation Point Query Service. Mapped to each ZCTA centroid coordinates. Last refreshed 2026-05-19.
- Last refreshed
- 2026-05-18.