Zip Code 45601
Chillicothe, Ohio — Ross County
📍 ZIP code 45601 is in Chillicothe, Ross County, Ohio.
ZIP code 45601 is located in Chillicothe, Ross County, Ohio. It is a zip code in the Eastern (EST/EDT) Time Zone with an estimated population of 56,453. The area code for ZIP code 45601 is 740.
Quick Answer
Zip code 45601 is in Chillicothe, Ohio (Ross County). It has a population of 56,453, median household income of $57,430, and median home value of $160,800.
Population
56,453
Income
$57,430
Home Value
$160,800
Climate
85°F / 21°F
About Zip Code 45601
Zip code 45601 is located in Chillicothe, Ohio, within Ross County. Home to approximately 56,453 residents, this area sits at an elevation of 605 ft and falls within the Eastern (EST/EDT) timezone. The local area code is 740.
The median household income is $57,430 per year, which is below the national median of $70,784. Homes in this zip code have a median value of $160,800, and the cost of living index is 63 (37% below the national average of 100).
Summers average a high of 85°F while winters drop to 21°F. The area receives about 45 in of rain and 9 in of snow annually. The zip code covers 341.9 square miles of land area and 3.3 square miles of water.
Key Statistics
56,453
$57,430
$160,800
Eastern (EST/EDT)
740
605 ft
341.9 sq mi
41.1
23,358
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Compare With Nearby Zip Codes
| Metric | 45601 | 45673 | 45644 | 45647 | 45690 | 45628 |
|---|---|---|---|---|---|---|
| City | Chillicothe, OH | Richmond Dale, OH | Kingston, OH | Chillicothe, OH | Waverly, OH | Frankfort, OH |
| Population | 56,453 | 600 | 4,561 | 2,276 | 13,315 | 5,670 |
| Median Income | $57,430 | $0 | $70,469 | $63,906 | $48,201 | $69,786 |
| Home Value | $160,800 | $88,700 | $215,800 | $173,100 | $153,500 | $167,500 |
| Cost of Living | 63 | 60 | 72 | 69 | 60 | 75 |
| Median Age | 41.1 | 26.8 | 47 | 52.9 | 42.3 | 40.8 |
Cost of Living
100 = National Average. Chillicothe's cost of living is 37% below the national average.
vs. State Avg
Below
Affordability
Very Affordable
Income-to-Home
2.8x
Demographics
Zip code 45601 has a population of 56,453 people with a median age of 41.1. There are 23,358 housing units in this area.
Racial & Ethnic Composition
Source: U.S. Census Bureau American Community Survey estimates.
Population History
Chillicothe (45601) population trend from 2010 to 2024
↑ 48.3%Source: U.S. Census Bureau estimates and American Community Survey data.
Climate & Weather
85°F
21°F
45 in
9 in
Chillicothe experiences warm summers with average highs around 85°F. Winters are cool with lows averaging 21°F. The area receives about 9 in of snow per year.
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Housing & Economy
Median Home Value
$160,800
Median Household Income
$57,430
With 23,358 housing units across 341.9 square miles, 45601 has a housing density of 68 units per square mile. The home price-to-income ratio is 2.8x.
Location & Geography
Latitude
39.3121°
Longitude
-82.9571°
Land Area
341.9 sq mi
Water Area
3.3 sq mi
Nearby Zip Codes
Zip codes closest to 45601 (Chillicothe, OH) with distances:
All Zip Codes in Chillicothe, OH
Other zip codes serving Chillicothe:
ZIP Codes with Similar Income Nationwide
The five U.S. ZIP codes whose median household income is closest to 45601's $57,430. A way to compare Chillicothe to economically similar communities elsewhere in the country.
Computed from U.S. Census Bureau ACS 5-Year Estimates by the Zip Code Near Me Data Team.
ZIP Codes with Similar Demographics
The five U.S. ZIP codes whose racial and ethnic composition most closely matches 45601 (Chillicothe, OH). Similarity is measured by cosine distance on the five-category ACS demographic vector.
Computed from U.S. Census Bureau ACS 5-Year Estimates by the Zip Code Near Me Data Team.
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People Also Ask
What zip code is Chillicothe, Ohio?
Chillicothe, Ohio uses zip code 45601 along with 2 other zip codes.
What county is zip code 45601 in?
Zip code 45601 is located in Ross County, Ohio.
What is the population of zip code 45601?
The population of zip code 45601 is 56,453 with a median age of 41.1.
Is 45601 in Chillicothe, Ohio?
Yes, zip code 45601 is in Chillicothe, Ross County, Ohio. The area code is 740.
Frequently Asked Questions
What city is zip code 45601 in?
Zip code 45601 is in Chillicothe, Ohio. It is part of Ross County and uses the Eastern (EST/EDT) timezone.
What is zip code 45601?
Zip code 45601 is a U.S. postal code in Chillicothe, Ohio (Ross County). It has a population of 56,453 and covers 341.9 square miles.
What is the population of zip code 45601?
The population of zip code 45601 (Chillicothe, OH) is 56,453 with a median age of 41.1. There are approximately 23,358 housing units in this area.
What is the median income in zip code 45601?
The median household income in zip code 45601 (Chillicothe, OH) is $57,430 per year. The cost of living index is 63 (100 = national average).
What is the average home price in zip code 45601?
The median home value in zip code 45601 (Chillicothe, OH) is $160,800. The cost of living index is 63 compared to the national average of 100.
What county is zip code 45601 in?
Zip code 45601 is located in Ross County, Ohio. The primary city is Chillicothe.
What is the area code for zip code 45601?
Zip code 45601 in Chillicothe, OH uses area code 740. It is located in the Eastern (EST/EDT) timezone.
Is zip code 45601 a good place to live?
Zip code 45601 (Chillicothe, OH) has a cost of living index of 63 (100 = national average), a median household income of $57,430, and median home values of $160,800. The median age is 41.1. Visit the full page for demographics, climate, and nearby zip code comparisons.
What is the cost of living in zip code 45601?
The cost of living index for zip code 45601 (Chillicothe, OH) is 63, where 100 represents the national average. This area is below the national average. Median home value: $160,800.
What schools serve zip code 45601?
Zip code 45601 in Chillicothe, Ohio is served by the local school district of Ross County. For specific school information, check your state's department of education or GreatSchools.org.
All demographic data on this page is sourced from the U.S. Census Bureau American Community Survey (ACS) 5-Year Estimates. ZIP code boundary and delivery data is sourced from the United States Postal Service (USPS). Data is updated periodically and may not reflect the most current figures. Census Bureau ZIP Code Tabulation Areas (ZCTAs) may differ slightly from USPS ZIP code boundaries.
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Data Sources
- Population, income, housing, age, and demographics
- U.S. Census Bureau, American Community Survey 5-Year Estimates, 2019-2023 vintage.
- ZIP to city and county mapping
- USPS and HUD-USPS ZIP-County Crosswalk.
- Time zones and area codes
- IANA tz database and NANPA.
- Elevation
- U.S. Geological Survey National Elevation Dataset (NED), via the USGS Elevation Point Query Service. Mapped to each ZCTA centroid coordinates. Last refreshed 2026-05-19.
- Last refreshed
- 2026-05-18.